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Nanocomposite materials in orthopedic applications

Mostafa R. Shirdar, Nasim Farajpour, Reza Shahbazian-Yassar, Tolou Shokuhfar

《化学科学与工程前沿（英文）》 2019年第13卷第1期页码 1-13 doi: 10.1007/s11705-018-1764-1

摘要：

This chapter is an introduction to nanocomposite materials and its classifications with emphasis on orthopedic application. It covers different types of matrix nanocomposites including ceramics, metal, polymer and natural-based nanocomposites with the main features and applications in the orthopedic. In addition, it presents structure, composition, and biomechanical features of bone as a natural nanocomposite. Finally, it deliberately presents developing methods for nanocomposites bone grafting.

关键词： nanocomposite materials orthopedic applications bone grafting nanocomposites nanocomposites classification

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Anodization of titanium alloys for orthopedic applications

Merve İzmir, Batur Ercan

《化学科学与工程前沿（英文）》 2019年第13卷第1期页码 28-45 doi: 10.1007/s11705-018-1759-y

摘要：

In recent years, nanostructured oxide films on titanium alloy surfaces have gained significant interest due to their electrical, catalytic and biological properties. In literature, there is variety of different approaches to fabricate nanostructured oxide films. Among these methods, anodization technique, which allows fine-tuning of oxide film thickness, feature size, topography and chemistry, is one of the most popular approaches to fabricate nanostructured oxide films on titanium alloys, and it has been widely investigated for orthopedic applications. Briefly, anodization is the growth of a controlled oxide film on a metallic component attached to the anode of an electrochemical cell. This review provides an overview of the anodization technique to grow nanostructured oxide films on titanium and titanium alloys and summarizes the interactions between anodized titanium alloy surfaces with cells in terms of cellular adhesion, proliferation and differentiation. It will start with summarizing the mechanism of nanofeatured oxide fabrication on titanium alloys and then switch its focus on the latest findings for anodization of titanium alloys, including the use of fluoride free electrolytes and anodization of 3D titanium foams. The review will also highlight areas requiring further research to successfully translate anodized titanium alloys to clinics for orthopedic applications.

关键词： titanium alloys anodization biocompatibility orthopedics

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Orthopedic management in the polytrauma patient

null

《医学前沿（英文）》 2012年第6卷第3期页码 234-242 doi: 10.1007/s11684-012-0218-2

摘要：

The past century has seen many changes in the management of the polytraumatized orthopedic patient. Early recommendations for non-operative treatment have evolved into early total care (ETC) and damage control orthopedic (DCO) treatment principles. These principles force the treating orthopaedist to take into account multiple patient parameters including hypothermia, coagulopathy and volume status before deciding upon the operative plan. This requires a multidisciplinary approach involving critical care physicians, anesthesiologists and others.

关键词： damage control orthopedics early total care polytrauma

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Special issue: Innovative applications of big data and artificial intelligence

《工程管理前沿（英文）》 2022年第9卷第4期页码 517-519 doi: 10.1007/s42524-022-0234-0

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Advanced biomass materials: progress in the applications for energy, environmental, and emerging fields

《化学科学与工程前沿（英文）》 2023年第17卷第7期页码 795-797 doi: 10.1007/s11705-023-2336-6

摘要： Advanced biomass materials: progress in the applications for energy, environmental, and emerging fields

关键词： progress applications energy fields

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A review on the forward osmosis applications and fouling control strategies for wastewater treatment

《化学科学与工程前沿（英文）》 2022年第16卷第5期页码 661-680 doi: 10.1007/s11705-021-2084-4

摘要： During the last decades, the utilization of osmotic pressure-driven forward osmosis technology for wastewater treatment has drawn great interest, due to its high separation efficiency, low membrane fouling propensity, high water recovery and relatively low energy consumption. This review paper summarizes the implementation of forward osmosis technology for various wastewater treatment including municipal sewage, landfill leachate, oil/gas exploitation wastewater, textile wastewater, mine wastewater, and radioactive wastewater. However, membrane fouling is still a critical issue, which affects water flux stability, membrane life and operating cost. Different membrane fouling types and corresponding fouling mechanisms, including organic fouling, inorganic fouling, biofouling and combined fouling are therefore further discussed. The fouling control strategies including feed pre-treatment, operation condition optimization, membrane selection and modification, membrane cleaning and tailoring the chemistry of draw solution are also reviewed comprehensively. At the end of paper, some recommendations are proposed.

关键词： forward osmosis wastewater treatment membrane fouling fouling control

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Applications of dynamical complexity theory in traditional Chinese medicine

null

《医学前沿（英文）》 2014年第8卷第3期页码 279-284 doi: 10.1007/s11684-014-0367-6

摘要：

Traditional Chinese medicine (TCM) has been gradually accepted by the world. Despite its widespread use in clinical settings, a major challenge in TCM is to study it scientifically. This difficulty arises from the fact that TCM views human body as a complex dynamical system, and focuses on the balance of the human body, both internally and with its external environment. As a result, conventional tools that are based on reductionist approach are not adequate. Methods that can quantify the dynamics of complex integrative systems may bring new insights and utilities about the clinical practice and evaluation of efficacy of TCM. The dynamical complexity theory recently proposed and its computational algorithm, Multiscale Entropy (MSE) analysis, are consistent with TCM concepts. This new system level analysis has been successfully applied to many health and disease related topics in medicine. We believe that there could be many promising applications of this dynamical complexity concept in TCM. In this article, we propose some promising applications and research areas that TCM practitioners and researchers can pursue.

关键词： traditional Chinese medicine Multiscale Entropy dynamical complexity system level applications

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Bridging the gap: Neuro-Symbolic Computing for advanced AI applications in construction

《工程管理前沿（英文）》页码 727-735 doi: 10.1007/s42524-023-0266-0

摘要： Deep Learning (DL) has revolutionized the field of Artificial Intelligence (AI) in various domains such as computer vision (CV) and natural language processing. However, DL models have limitations including the need for large labeled datasets, lack of interpretability and explainability, potential bias and fairness issues, and limitations in common sense reasoning and contextual understanding. On the other side, DL has shown significant potential in construction for safety and quality inspection tasks using CV models. However, current CV approaches may lack spatial context and measurement capabilities, and struggle with complex safety and quality requirements. The integration of Neuro-Symbolic Computing (NSC), an emerging field that combines DL and symbolic reasoning, has been proposed as a potential solution to address these limitations. NSC has the potential to enable more robust, interpretable, and accurate AI systems in construction by harnessing the strengths of DL and symbolic reasoning. The combination of symbolism and connectionism in NSC can lead to more efficient data usage, improved generalization ability, and enhanced interpretability. Further research and experimentation are needed to effectively integrate NSC with large models and advance CV technologies for precise reporting of safety and quality inspection results in construction.

关键词： advanced AI in construction safety and quality inspection Neuro-Symbolic Computing Deep Learning computer vision

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A brief review on nonlinear modeling methods and applications of compliant mechanisms

Guangbo HAO,Jingjun YU,Haiyang LI

《机械工程前沿（英文）》 2016年第11卷第2期页码 119-128 doi: 10.1007/s11465-016-0387-9

摘要：

Compliant mechanisms (CMs) have become one of the most popular research themes in mechanisms and robotics because of their merits. This paper aims to provide a brief systematic review on the advances of nonlinear static modeling approaches and the applications of CMs to promote interdisciplinary/multidisciplinary development for associated theories and other new applications. It also predicts likely future directions of applications and theory development.

关键词： compliant mechanisms modelling nonlinearity applications review

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Design and applications of morphing aircraft and their structures

《机械工程前沿（英文）》 2023年第18卷第3期 doi: 10.1007/s11465-023-0750-6

摘要： Morphing aircraft can adaptively regulate their aerodynamic layout to meet the demands of varying flight conditions, improve their aerodynamic efficiency, and reduce their energy consumption. The design and fabrication of high-performance, lightweight, and intelligent morphing structures have become a hot topic in advanced aircraft design. This paper discusses morphing aircraft development history, structural characteristics, existing applications, and future prospects. First, some conventional mechanical morphing aircraft are examined with focus on their morphing modes, mechanisms, advantages, and disadvantages. Second, the novel applications of several technologies for morphing unmanned aerial vehicles, including additive manufacturing for fabricating complex morphing structures, lattice technology for reducing structural weight, and multi-mode morphing combined with flexible skins and foldable structures, are summarized and categorized. Moreover, in consideration of the further development of active morphing aircraft, the paper reviews morphing structures driven by smart material actuators, such as shape memory alloy and macro-fiber composites, and analyzes their advantages and limitations. Third, the paper discusses multiple challenges, including flexible structures, flexible skins, and control systems, in the design of future morphing aircraft. Lastly, the development and application of morphing structures in the aerospace field are discussed to provide a reference for future research and engineering applications.

关键词： morphing aircraft additive manufacturing lattice structure smart material flexible structure flexible skin

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Biological properties and clinical applications of berberine

Danyang Song, Jianyu Hao, Daiming Fan

《医学前沿（英文）》 2020年第14卷第5期页码 564-582 doi: 10.1007/s11684-019-0724-6

摘要： Berberine, an isoquinoline alkaloid isolated from the Chinese herb and other plants, has a wide range of pharmacological properties. Berberine can be used to treat many diseases, such as cancer and digestive, metabolic, cardiovascular, and neurological diseases. Berberine has protective capacities in digestive diseases. It can inhibit toxins and bacteria, including , protect the intestinal epithelial barrier from injury, and ameliorate liver injury. Berberine also inhibits the proliferation of various types of cancer cells and impedes invasion and metastasis. Recent evidence has confirmed that berberine improves the efficacy and safety of chemoradiotherapies. In addition, berberine regulates glycometabolism and lipid metabolism, improves energy expenditure, reduces body weight, and alleviates nonalcoholic fatty liver disease. Berberine also improves cardiovascular hemodynamics, suppresses ischemic arrhythmias, attenuates the development of atherosclerosis, and reduces hypertension. Berberine shows potent neuroprotective effects, including antioxidative, antiapoptotic, and anti-ischemic. Furthermore, berberine exerts protective effects against other diseases. The mechanisms of its functions have been extensively explored, but much remains to be clarified. This article summarizes the main pharmacological actions of berberine and its mechanisms in cancer and digestive, metabolic, cardiovascular, and neurological diseases.

关键词： berberine Coptis chinensis pharmacological properties mechanism clinical applications

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Environmental applications and implications of nanotechnologies

Dongye ZHAO,Shubo DENG

《环境科学与工程前沿（英文）》 2015年第9卷第5期页码 745-745 doi: 10.1007/s11783-015-0810-1

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Additive manufacturing: technology, applications and research needs

Nannan GUO, Ming C. LEU

《机械工程前沿（英文）》 2013年第8卷第3期页码 215-243 doi: 10.1007/s11465-013-0248-8

摘要：

Additive manufacturing (AM) technology has been researched and developed for more than 20 years. Rather than removing materials, AM processes make three-dimensional parts directly from CAD models by adding materials layer by layer, offering the beneficial ability to build parts with geometric and material complexities that could not be produced by subtractive manufacturing processes. Through intensive research over the past two decades, significant progress has been made in the development and commercialization of new and innovative AM processes, as well as numerous practical applications in aerospace, automotive, biomedical, energy and other fields. This paper reviews the main processes, materials and applications of the current AM technology and presents future research needs for this technology.

关键词： additive manufacturing (AM) AM processes AM materials AM applications

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Base editors: development and applications in biomedicine

《医学前沿（英文）》 2023年第17卷第3期页码 359-387 doi: 10.1007/s11684-023-1013-y

摘要： Base editor (BE) is a gene-editing tool developed by combining the CRISPR/Cas system with an individual deaminase, enabling precise single-base substitution in DNA or RNA without generating a DNA double-strand break (DSB) or requiring donor DNA templates in living cells. Base editors offer more precise and secure genome-editing effects than other conventional artificial nuclease systems, such as CRISPR/Cas9, as the DSB induced by Cas9 will cause severe damage to the genome. Thus, base editors have important applications in the field of biomedicine, including gene function investigation, directed protein evolution, genetic lineage tracing, disease modeling, and gene therapy. Since the development of the two main base editors, cytosine base editors (CBEs) and adenine base editors (ABEs), scientists have developed more than 100 optimized base editors with improved editing efficiency, precision, specificity, targeting scope, and capacity to be delivered in vivo, greatly enhancing their application potential in biomedicine. Here, we review the recent development of base editors, summarize their applications in the biomedical field, and discuss future perspectives and challenges for therapeutic applications.

关键词： base editing CBE ABE ADAR DdCBE disease model therapeutic application

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New response surface model and its applications in aerodynamic optimization of axial compressor blade

LIU Xiaojia, NING Fangfei

《能源前沿（英文）》 2008年第2卷第4期页码 541-549 doi: 10.1007/s11708-008-0077-3

摘要： A parametric method for the axial compressor 2D blade profiles is proposed in which the blade geometries are defined with the parameters commonly used for blade definition, which ensures that the geometric significance is clear and an unreasonable blade profile is not generated. Several illustrations are presented to show the fitting precision of the method. A novel response surface model is proposed which regards the objective distribution function in the vicinity of a sample as normal school, and then generates the response surface function in the whole design space by a linear combination of distribution functions of all the samples. Based on this model, a numerical aerodynamic optimization platform for the axial compressor 2D blade profiles is developed, by which aerodynamic optimization of two compressor blade profiles are presented.

关键词： definition objective distribution fitting precision combination numerical aerodynamic